Childhood TB Subgroup

Documents developed by the Childhood TB Subgroup

Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children (Portuguese version)
This document represents consensus guidance developed by the childhood TB subgroup (one of the subgroups of the DOTS Expansion Working Group, under the overall auspices of the Stop TB Partnership). It has been published in a shorter form as a series of papers in the International Journal of TB and Lung Disease:
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5

Ethambutol efficacy and toxicity:
literature review and recommendations for daily and intermittent dosage in children
This document reviews the published evidence relating to the dosage, toxicity and pharmacokinetics of ethambutol in children and adults and makes a recommendation for a revised daily dose of ethambutol to be used in children. In view of the almost total lack of ocular toxicity in children of all ages receiving ethambutol at doses of from 15-30 mg/kg documented in this review it can be recommended that children of all ages can be given ethambutol in daily doses of 20 mg/kg (range 15-25 mg/kg) and three times weekly intermittent doses of 30 mg/kg body weight without undue concern. The document is also published in a shorter form in the International Journal of TB and Lung Disease:
Donald PR, Maher D, Maritz JS, Qazi S. Ethambutol dosage for the treatment of children: literature review and recommendations. International Journal of Tuberculosis and Lung Disease 10(12):1318-1330