Xpert MTB/RIF roll-out
WHO endorses new rapid tuberculosis test
Background
Earlier and improved tuberculosis (TB) case detection - including smear-negative disease, often associated with HIV co-infection - as well as expanded capacity to diagnose multidrug-resistant tuberculosis (MDR-TB) are global priorities for TB control. Conventional laboratory methods are slow and cumbersome and novel technologies for rapid detection are therefore the focus of TB research and development. With support from NIH, the Foundation for Innovative New Diagnostics (FIND) has partnered with Cepheid, Inc. (Sunnyvale, CA) and the University of Medicine and Dentistry of New Jersey (UMDNJ, Newark, NY) to develop a TB-specific automated, cartridge-based nucleic amplification assay (Xpert MTB/RIF) based on the GeneXpert multi-disease platform, currently unique in its simplification of molecular testing with fully integrated and automated sample preparation, amplification and detection required for real-time polymerase chain reaction. Xpert MTB/RIF detects M. tuberculosis as well as rifampicin resistance-conferring mutations directly from sputum, in an assay providing results within two hours.
WHO policy statement on Xpert MTB/RIF
Rapid Implementation document of the Xpert MTB/RIF diagnostic test
Checklist
Updates on Xpert MTB/RIF roll out
Published evidence on Xpert MTB/RIF
Fact sheet, pdf, 38kb
WHO monitoring of Xpert MTB/RIF roll-out
Meetings on Xpert MTB/RIF
April 2012
4th Annual GLI Meeting/Consultation of the SRL network/Early implementers meeting on Xpert MTB/RIF roll out
Les Pensières, Veyrier-du-Lac, France
17-19 April 2012
Agenda and presentations
List of Participants
May 2011
Consultation: Impact of WHO-endorsed molecular diagnostics on TB and MDR-TB case- and treatment outcome definitions
Agenda
Background Information
List of Participants
Geneva, Thurs + Fri 12-13 May
Presentations:
1.DF_Overview of current MDR-TB case and treatment outcome definitions 12 May 2011
Case and outcome definitions 11May11 Grzemska
Consultation 12-13 May 2011 KWEYER.pptx
Objectives_ExpectedOutcomes Floyd
Objectives_ExpectedOutcomes_20110513
Objectives_ExpectedOutcomes_20110516
revising_casedef_rev_pg
revising_outcomes_defs_pg
April 2011
Implementation and roll-out of the Xpert MTB/RIF system for rapid diagnosis of tuberculosis and multidrug-resistance: Workshop for Early Implementers
Date & time: 7-8 April 2011, 08:00 - 17:00
Venue: Starling Geneva Hotel & Conference Center
34, route François Peyrot, 1218 Le Grand Saconnex, Geneva, Switzerland
Agenda
Background materials
Presentations
Day 1
- Session1a_Timeline of Xpert MTBRIF activities [.pdf]
- Session1b_Workshop scope and objectives [.pdf]
- Session2a_Xpert MTBRIF development, analytical performance and evidence from field evaluation studies [.pdf]
- Session2b_Xpert MTBRIF operational considerations [.pdf]
- Session3a_Risk assessment [.pdf]
- Session3b_Primary considerations_Individuals at risk of MDRTB [.pdf]
- Session3c_Primary considerations_People living with HIV [.pdf]
- Session3d_Secondary considerations [.pdf]
- Session3e_Site selection [.pdf]
Day 2
- Session4a and b_Preferential pricing, installation and startup costs, and post-marketing surveillance [.pdf]
- Session4c_Involvement of the private sector [.pdf]
- Session4d_Uganda experience using Xpert MTBRIF [.pdf]
- Session5a_Interim case definitions MG 8Apr11 [.pdf]
- Session5b_Registration and reporting of TB and MDR-TB [.pdf]
- Session5c_Management of patients with rifampicin resistance [.pdf]
- Session5d_Managing of persons with HIVassociated TB [.pdf]
- Session6a_Plans- CDC_PEPFAR [.pdf]
- Session6a_Plans- FIND EXPAND-TB [.pdf]
- Session6a_Plans- ICAP [.pdf]
- Session6a_Plans- IOM [.pdf]
- Session6a_Plans- KNCV [.pdf]
- Session6a_Plans- Moldova [.pdf]
- Session6a_Plans- MSF [.pdf]
- Session6a_Plans- South Africa NHLS [.pdf]
- Session6a_Plans- USAID [.pdf]
- Session6b_Way forward and next steps [.pdf]
- Session7a_Operational research opportunities and priorities [.pdf]
- Session7b_Operational research and implementation of new TB diagnostics [.pdf]
- Session7b_Xpert operational research mapping tool [.pdf]
February 2011
Update on the implementation and roll out of the Xpert MTB/RIF
Date & time: 21 February 2011, 14:00 - 16:00
Venue: Room 605, Building M, World Health Organization, Geneva
Background Materials
Update note on the implementation and roll-out of Xpert MTB/RIF
Roadmap for rolling our Xpert MTB/RIF
Frequently Asked Question on Xpert MTB/RIF
FIND update on operational questions regarding the Xpert MTB/RIF test
Cartridge Video
Presentations
Briefing Xpert MTB-RIF
Implementation of Xpert FM
December 2010
GLOBAL CONSULTATION ON THE IMPLEMENTATION AND SCALE-UP OF THE "GeneXpert MTB/RIF System" FOR RAPID DIAGNOSIS OF TB AND MDR-TB
Date and time: 30 November -02 December 2010, 09:00 - 18:00
Venue: Centre International de Conférences de Genève (CICG)
17, Rue Varembé, Geneva, Switzerland
Agenda
Presentations
Day 1
session 1
- Meeting scope and objectives K Weyer [.pdf]
- New frontiers changing diagnostic paradigms G Roscigno [.pdf]
- Responding to change Rapid policy development by WHO M Raviglione K Weyer [.pdf]
session 2
- Xpert MTB RIF - development and analytical performance M Perkins [.pdf]
- Xpert MTB RIF - evidence and operational considerations C Boehme [.pdf]
- Xpert MTB RIF - update on price negotiations and market dynamics G Roscigno [.pdf]
session 3
- An ethical dillemma - diagnosis without treatment A Reis [.pdf]
- From diagnosis to treatment and care - the missing links P Nunn [.pdf]
- Xpert MTB RIF - opportunity to enhance private sector engagement M Uplekar [.pdf]
- Xpert MTB RIF - scenarios for cost effectiveness A Vassall [.pdf]
- Xpert MTB RIF in the Global plan 2011-2015 - what it will cost K Floyd [.pdf]
session 4
- Civil society perspective F Varaine [.pdf]
- Civil society perspective J Syed [.pdf]
- Pateint Perspectives on GeneXpert L Chesire N Otwoma [.pdf]
- Use of Xpert MTB RIF in the private sector - Pakistan A Khan [.pdf]
session 5
- Global Consultation Algorithm Xpert DOTS Expansion [.pdf]
- Global Consultation Algorithm Xpert TBHIV [.pdf]
- Global Consultation Xpert Algorithm MDR-TB [.pdf]
Day 2
- Discussion on diagnostic algorithm with Xpert DOTS Expansion [.pdf]
- Discussion on diagnostic algorithm with Xpert MDR-TB [.pdf]
- Discussion on diagnostic algorithm with Xpert TB HIV [.pdf]
Day 3
- Country plan for scaling up Xpert MTB-RIF G Coetzee [.pdf]
- Final diagnostic algorithm with Xpert MDR D Falzon [.pdf]
- Final diagnostic algorithm with Xpert DOTS Expansion S Sahu [.pdf]
- Final diagnostic algorithm with XpertTB HIV D Sculier [.pdf]
- Global Roadmap for scaling up Xpert MTB-RIF K Weyer [.pdf]
- Increasing access to vulnerable groups through TB REACH L Ditiu [.pdf]
- Learning by doing through EXPAND-TB E Adam [.pdf]
- Mobilising country capacity through TB CARE A Piatek [.pdf]
- Targeting HIV settings through PEPFAR B Coggin [.pdf]
- Xpert_TBHIV_ambulatory_02 12 10_v1 [.pdf]
- Xpert_TBHIV_seriously ill_02 12 01_v1doc [.pdf]