Practical manual on tuberculosis laboratory strengthening updated to support the implementation of WHO-recommended diagnostics
24 January 2023 -The Practical manual on TB laboratory strengthening was released today to support implementation of World Health Organization (WHO) recommended TB diagnostics through quality assured TB laboratory services and networks. The document is an update of the GLI Practical Guide to TB Laboratory Strengthening issued in 2017 and is now aligned with the latest WHO recommendations on new tools to diagnose tuberculosis and detect drug resistance.
The updated manual provides an overview of the WHO recommendations and model algorithms as well as addressing key technical areas covering the TB laboratory network, quality management systems, sample collection and transport, biosafety, and operational management of a laboratory.
The update was developed by the Stop TB Partnership’s Global Laboratory Initiative working group, with its secretariat at the World Health Organization (WHO) Global TB Programme and is available through the respective websites.
TB laboratory manuals issued to support the implementation of WHO-recommended diagnostics
13 May 2022 - Three new manuals were released today to support the implementation of molecular WHO-recommended rapid diagnostic tests for the detection of TB and drug-resistant TB, the processing of stool samples for the diagnosis of childhood TB and the interpretation and reporting of line probe assays (LPAs) for detection of drug-resistant TB. These manuals were developed by WHO and the Stop TB Partnership’s Global Laboratory Initiative (GLI) working group.
The first product assists implementers in the assessment of the most appropriate technologies to detect tuberculosis (TB) and drug resistant TB (DR-TB) in their settings. The manual includes a description of the tests, which data and the types of analyses are needed to make an informed decision, and a decision tree to select the most suitable testing technologies based on setting-specific situational analysis.
The second product provides practical information to implement the recent WHO recommendations for using stool, a child-friendly sample type, to detect TB and resistance to rifampicin in children using the Xpert MTB/RIF and/or Xpert MTB/RIF Ultra tests. The manual includes a description of two processing methods, steps to perform the methods and implementation considerations.
The third document updates the GLI guide for the interpretation and reporting of line probe assays that was released in 2018. The revisions incorporate updates in the interpretation of mutations associated with TB drug resistance to align with the latest information in the 2021 WHO Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. The manual includes a description of LPAs for detection of TB drug resistance, a standardized interpretation of results for both first- and second-line drugs, and case studies for practical demonstration.
- Manual for selection of molecular WHO-recommended rapid diagnostic tests for detection of tuberculosis and drug-resistant tuberculosis
- Practical manual of processing stool samples for diagnosis of childhood TB
- Line probe assays (LPA) for detection of drug-resistant tuberculosis: interpretation and reporting manual for laboratory staff and clinicians
The documents are also available on the WHO Global TB Programme website.
GLI Core Group elects new Chair and welcomes four new members
The GLI Core Group is happy to announce the election of a new Chair and four new members for the 2022-2023 term. Dr. Marguerite Massinga Loembé, member of the Core Group since 2021, was elected Chair by majority vote. Dr. Massinga Loembé is a Senior Science Manager at the African Society for Laboratory Medicine (ASLM) in Libreville, Gabon. In addition, four new Core Group members were selected by objective review of applications and include: Dr. Andrea Cabibbe, a Research Associate at the San Raffaele Scientific Institute, Milano, Italy; Dr. Sushil Pandey, the Chief Scientist at Queensland Mycobacterium Reference Laboratory, Brisbane, Australia; Dr. Leen Rigouts, the Senior Scientific Expert at the Institute of Tropical Medicine, Antwerp, Belgium; and Dr. Léon Sawadogo, the Laboratory Manager at the Centre National de Lutte Antituberculeuse (CNLAT), Ouagadougou, Burkina Faso. While welcoming these new TB laboratory experts to GLI, the Core Group would like to express deep thanks to the members that have completed their terms – Dr. Maka Akhalaia, Dr. Uladzimir Antonenka, and Dr. Abiola Tubi - for years of expert contributions to Initiate.
Planning and Budgeting Tool for TB and drug resistant TB testing
The Global Laboratory Initiative (GLI), with its secretariat at the World Health Organization (WHO) Global TB Programme, is pleased to release a Planning and Budgeting Tool for TB and Drug Resistant TB Testing for calculation of quantities and costs of diagnostic products and laboratory supplies. The tool references product numbers and prices in the Stop TB Partnership Global Drug Facility (GDF) Diagnostics, Medical Devices, and other Health Products Catalog.
The toolkit includes a semi-automated, editable, Excel-based calculation tool and an accompanying User Guide that explains editable fields and methods for calculation of goods within each Excel worksheet. Importantly, tool calculations take country-specific epidemiology and diagnostic algorithms into account when considering each user’s diagnostic product and laboratory supply needs. Worksheets with calculation tables are included for all WHO recommended diagnostic and drug susceptibility testing methods as well as items related to biosafety, cleaning, equipment maintenance and repair.
The tool presents users with an automated annual Budget Summary that provide users with an overview of items for testing, cleaning, and biosafety as well as maintenance and repair costs. Lastly, an automated annual Laboratory Items Summary provides a list of all items to be purchased and associated total costs based on user inputs.
The Tool and User Guide are available on the GLI website and on the WHO website.
New GLI Core Group Members
28 July 2021 - The Global Laboratory Initiative (GLI) is happy to announce the election of three technical experts who joined the GLI Core Group this month: Alex Durena, Kristin Kremer and Tetsuhiro Sugamoto.
The many experiences and perspectives they bring to GLI will be of great benefit to continuing building and sustaining high-quality TB diagnostic networks and strengthening laboratory capacity at the country, regional and global level. For more information about the Core Group, please click here.
GLI core group collaborates with various partners on the development of the "Score TB Package"
26 May 2021 - GLI is pleased to announce the launch of the Score-TB package, a tool to help build quality-assured TB testing and management capacity utilizing the SLIPTA methodology. The Score TB Package combines TB test-specific Scorecards and the SLIPTA checklist in traditional and automated e-tool formats to facilitate user-friendly quality assessment of modern TB laboratories.
The Score-TB Package is intended to inform Ministry of Health officials, health facility and laboratory managers, donors, implementing partners, quality assurance personnel, programme managers and supervisory staff at national, regional and facility levels on international standards for delivering quality-assured TB testing and serve as a comprehensive, updated toolkit for quality management system assessment at individual TB laboratories. For more information, please click here.