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Organization Contact Information

Name: Parabolic Biologicals
Street 1: Rue de l'Ecluse 2
Street 2:
City: Beauvechain
Province:
Post Code: 1320
Country: Belgium
Phone: +3310818360
Email: d.maes@parabolic.be
Web Site: http://www.bioparabolic.com

Focal Point Contact Information

Salutation: Mrs
First Name: Dominique
Last Name: Maes
Title: Director
Email: d.maes@parabolic.be
Phone: +3310818361

Alternate Focal Point Contact Information

Salutation: Mrs
First Name: Dominique
Last Name: Maes
Title: Director
Email: d.maes@parabolic.be
Phone: +3210818361

General Information

Board Constituency: Private sector
Organization Type - Primary: Private Sector
Organization Type - Secondary: Business Association
Is your organization legally registered in your country: Yes
Organization Reach: International
Organization Description:
A company selling food supplements to help patients support better heavy treatments (aids, tuberculosis, cancer etc..). We have recently pattented a molecule that might have a great interest for tuberculosis patients. Uleine promotes the production of nitric oxide (NO) by macrophages and reduces in this way the susceptibility of the organism in a preventive way to the destabilizing action of invading pathogens as well as of internally produced cells that escape the normal immunological homeostasis of the organism, and initiate an uncontrolled multiplication, i.e. a tumor.
 
Total number of staff in your organization: 1 - 5
Number of full-time staff who are directly involved with TB: 1 - 5
Number of part-time staff who are directly involved with TB: 0
Number of volunteers who are directly involved with TB: 0
 
What is your organization's annual budget (USD) dedicated to TB? < $1,000
How did you hear about the Stop TB Partnership: Other partners
If you were informed or referred by another partner of the Stop TB Partnership please tell us who:
Why do you wish join the Stop TB Partnership: Network with other partners
 
Are you a member of a Stop TB national partnership: No
Are you in contact with your national TB programme: No
Please tell us how your organization is contributing to your country's national TB control plan:
We are not yet involved in it but have contacted the TB control center in Belgium and France and are looking at ways to contribute to their program.

Our former director Dr Maes, has been in the past greatly involved in TB research and was member of the International Mycobacterium society.
 

Geographical Reach

Which country is your headquarters located in: Belgium
Which WHO region is the main focus of your work: African
Which countries do you do operate in:
(This includes countries you are conducting activities in)
Congo

Specializations

Provision of drugs, diagnostics and commodities

Specializations in Countries

Provision of drugs, diagnostics and commodities Congo

Contribution

Please tell us how your organization will contribute to the Global Plan to Stop TB by briefly describing its involvement in any of the areas of work listed below:

TB Care Delivery:
The DOTS regimen leaves a variable number of patients non cured.This evidence indicates that the regimen may need help to maximize its activity. Our company is proud to make available a food supplement (Para pau aspido) whose active principle is Uleine. This molecule boosts the production of Nitric Oxide (NO) by macrophages. It has been shown very useful in the treatment of AIDS patients:
https://drive.google.com/file/d/0B-rH5q_guaV2Q3dEUXJOWEFocWc/edit?usp=sharing

and must be equally active against TB because the germs multiply in macrophages and inhibit the production of NO by these macrophages.
The quality of the food supplement has been published in the following publication:
https://drive.google.com/file/d/0B-rH5q_guaV2ODlrZVhJMFZJdFU/edit?usp=sharing
which demonstrates that the extraction and purification of the active principle proceeded with the utmost care.

Drug-Resistant TB:
The number of Drug-reststant strains of TB has increased in the last years, some of them resisting all known available drugs. To assist in the fight against TB, a new unspecific drug may be of help, which would not be specific for TB but which would rather boost the immune reactivity of the patient. It is well known that TB is immunosouppressive and an immuno-potentiator would be of help to combat it. We are proud to present to the Stop-TB partnership the food supplement Para Pau aspido, whose main active principle is Uleine. This molecule was shown to boost the synthesis of Nitric Oxide in macrophages and was shown of great help in the treatment of AIDS patients. The clinical study performed on AIDS patients is given here:
https://drive.google.com/file/d/0B-rH5q_guaV2Q3dEUXJOWEFocWc/edit?usp=sharing
The extraction and purification of the uleine incorporated in the food supplement has been published by the revista brazileira de Farmacognosia and is given here:
https://drive.google.com/file/d/0B-rH5q_guaV2ODlrZVhJMFZJdFU/edit?usp=sharing

This publication underlines the seriousness of the process.
We are confident that the various groups of the Stop-Tb partnership will appreciate the benefits offered by this food supplement in its fight against TB and HIV.


TB-HIV:
We have patented a molecule called Uleine which we are sure will be of great interest to HIV and TB patients. Uleine promotes the synthesis of the powerfully reactive chemical nitric oxide (NO) and reduces the susceptibility of the organism in a preventive way to infection by invading pathogens as well as of internally produced tumor cells that escape the normal immunological homeostasis of the organism. Nitric oxide is the primary molecule synthesized by macrophages and other cells pertaining to the immune system to inactivate external and internally produced destabilizing agents as viruses, bacteria and cancers. Some pathogens, as the HIV and Tuberculosis, multiply in macrophages and other immune cells and thus directly impact their capacity to destroy the pathogens.
The following document pr├ęsents the results of a clinical study made on AIDS patients:
https://drive.google.com/file/d/0B-rH5q_guaV2Q3dEUXJOWEFocWc/edit?usp=sharing
The results obtained are spectacular and we are confident that the Stop TB partnership members will fullmy appreciate the benefits this food supplement will give th AIDS patients.
The extraction and purification of the Uleine incorporated to the food supplement PARA PAU aspido has been published by the Revista brazileira de Farmacognosia :
https://drive.google.com/file/d/0B-rH5q_guaV2ODlrZVhJMFZJdFU/edit?usp=sharing
and demonstrates the seriousness with which these processes were accomplished.



Declaration

Declaration of interests:
No conflicts of interest were delacred.

Application date: July 16, 2014
Last updated: July 17, 2014